Microdomains Displace Laterally and Rotate in the Plasma Membrane of Cochlear Outer Hair Cells
نویسندگان
چکیده
منابع مشابه
Microdomains shift and rotate in the lateral wall of cochlear outer hair cells.
Outer hair cell (OHC) electromotility, a response consisting of reversible changes in cell length and diameter induced by electrical stimulation, confers remarkable sensitivity and frequency resolution to the mammalian inner ear. Looking for a better understanding of this mechanism, we labeled isolated guinea pig OHCs with microspheres and, using high-speed video recording, investigated their m...
متن کاملCochlear amplification, outer hair cells and prestin.
Mechanical amplification of acoustic signals is apparently a common feature of vertebrate auditory organs. In non-mammalian vertebrates amplification is produced by stereociliary processes, related to the mechanotransducer channel complex and probably to the phenomenon of fast adaptation. The extended frequency range of the mammalian cochlea has probably co-evolved with a novel hair cell type, ...
متن کاملPrestin and the dynamic stiffness of cochlear outer hair cells.
The outer hair cell (OHC) lateral wall is a unique trilaminate structure consisting of the plasma membrane, the cortical lattice, and subsurface cisternae. OHCs are capable of altering their length in response to transmembrane voltage change. This so-called electromotile response is presumed to result from conformational changes of membrane-bound protein molecules, named prestin. OHC motility i...
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The sensitivity of the mammalian inner ear is extraordinary. At the threshold of hearing, the incoming sound produces vibrations inside the organ of Corti that are of the same order of magnitude or less than the thermal noise motion (Hudspeth, 1989, 1997; Dallos, 1996). Such sensitivity is achieved through an energy-dependent process commonly referred to as “cochlear amplifier,” i.e., the cycle...
متن کاملCharacterization of transcriptomes of cochlear inner and outer hair cells.
Inner hair cells (IHCs) and outer hair cells (OHCs) are the two types of sensory receptor cells that are critical for hearing in the mammalian cochlea. IHCs and OHCs have different morphology and function. The genetic mechanisms that define their morphological and functional specializations are essentially unknown. The transcriptome reflects the genes that are being actively expressed in a cell...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2012
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2011.11.1652